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Opened capsules Opened 2358
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Sealed in 09 August 2015 09:59:41
Opened at: 04 May 2020 15:30:00
Sealed with Dogecoin Medical Prediction: Immunotherapy replaces chemotherapy as the standard cancer treatment

Terminally ill cancer patients could be “effectively cured” of the disease using a powerful new combination of drugs described by scientists as heralding a once-in-a-generation advance in treatment.

A British-led trial brought “spectacular” results with more than half of patients with advanced melanoma seeing tumours shrink or brought under control using the drugs.

Prof Roy Herbst, chief of medical oncology at Yale Cancer Centre in the US, said the treatment, which uses the body’s immune system to attack cancerous cells, could potentially replace chemotherapy as the standard cancer treatment within five years.

“I think we are seeing a paradigm shift in the way oncology is being treated,” he said. “The potential for long-term survival, effective cure, is definitely there.”

In an international trial, 945 patients with advanced melanoma were treated using the drugs ipilimumab and nivolumab. The treatments stopped cancer advancing for nearly a year in 58% of cases, with tumours stable or shrinking for an average of 11.5 months, researchers found.

This was compared with 19% of cases for ipilimumab alone, with tumours stable or shrinking for an average of two and a half months, according to the research published in the New England Journal of Medicine.

Dr James Larkin, a consultant at the Royal Marsden hospital and one of the UK’s lead investigators, told the BBC: “By giving these drugs together you are effectively taking two brakes off the immune system rather than one, so the immune system is able to recognise tumours it wasn’t previously recognising and react to that and destroy them.

“For immunotherapies, we’ve never seen tumour shrinkage rates over 50% so that’s very significant to see. This is a treatment modality that I think is going to have a big future for the treatment of cancer.”

Ipilimumab was approved as an advanced melanoma treatment by the UK’s health service last year. The drug is given intravenously every three months and costs around £100,000 for a year. Nivolumab is given every two weeks until it stops working.

Dr Alan Worsley, Cancer Research UK’s senior science information officer, said the combination of ipilimumab and nivolumab represented a “a powerful one-two punch” against advanced melanoma.

He added: “Together these drugs could release the brakes on the immune system while blocking cancer’s ability to hide from it. But combining these treatments also increases the likelihood of potentially quite severe side-effects. Identifying which patients are most likely to benefit will be key to bringing our best weapons to bear against the disease.”

Side-effects can include fatigue, rash and diarrhoea.

Eminent oncologist Prof Karol Sikora, the dean of the University of Buckingham’s medical school, cautioned against expectations of “miraculous breakthroughs” from the latest discoveries.

Sikora told the BBC Radio 4 Today programme: “The immune system has been known to affect certain cancers when stimulated for the last 100 years, but we haven’t quite got round it yet.

“The current discoveries being released in Chicago, the media pick them up and for cancer patients it’s very sad. You would think cancer was being cured tomorrow. It’s not the case. We’ve got a lot to learn.

“The prolongation of survival from these very expensive immune therapies is often a matter of weeks or months and we’ve got to make it long-lasting and that has to be our priority.

“I’m afraid it’s mixed news. There are breakthroughs coming, there is hope for cancer, that we will do much better in the future. It’s slow progress, rather than miraculous breakthroughs, as it’s likely to be reported.”

Case study

One patient who has benefited from the treatment is former college teacher Vicky Brown, 61, who was told in 2013 she had only months to live after skin cancer spread to her breast and lungs.

She took part in clinical trials at the Royal Marsden hospital last August and within weeks the tumour was eradicated. When it later returned, it was removed with immunotherapy. It has come back a third time but doctors plan to use the same method.

“I started drug therapy in August 2014, and although I experienced quite severe side-effects these were able to be treated so I could stay on the trial,” Brown said.

“One of the lumps disappeared after just a couple of weeks which was remarkable. I was delighted to be given the chance to join this trial, not only for me, but also for all the other melanoma patients who could benefit in the future.”


Age: 58 months Observers 0 Views : 806 Owner: E-type
Owner: E-type
Sealed in 15 May 2017 21:46:37
Opened at: 30 April 2020 22:00:00
All publicly funded scientific papers published in Europe are now free to access

All publicly funded scientific papers published in Europe could be made free to access by 2020, under a “life-changing” reform ordered by the European Union’s science chief, Carlos Moedas.

The Competitiveness Council, a gathering of ministers of science, innovation, trade and industry, agreed on the target following a two-day meeting in Brussels last week.

The move means publications of the results of research supported by public and public-private funds would be freely available to and reusable by anyone. It could affect the paid-for subscription model used by many scientific journals, and undermine the common practice of releasing reports under embargo.

At present the results of some publicly funded research are not accessible to people outside universities and similar institutions without one-off payments, which means that many teachers, doctors, entrepreneurs and others do not have access to the latest scientific insights. In the UK, funding bodies generally require that researchers publish under open access terms, with open access publishing fees paid from the researcher’s grant.

The council said this data must be made accessible unless there were well-founded reasons for not doing so, such as intellectual property rights or security or privacy issues.

The changes are part of a broader set of recommendations in support of Open Science, a concept that also includes improved storage of and access to research data, Science magazine reports.

Open Science has been heavily lobbied for by the Dutch government, which currently holds the presidency of the Council of the EU, as well as by Moedas, the European commissioner for research and innovation.

Moedas told a press conference: “We probably don’t realise it yet, but what the Dutch presidency has achieved is unique and huge. The commission is totally committed to help move this forward.”

Sander Dekker, the Dutch state secretary for education, culture, and science, said in a statement: “Research and innovation generate economic growth and more jobs and provide solutions to societal challenges. And that means a stronger Europe.

“To achieve that, Europe must be as attractive as possible for researchers and startups to locate here and for companies to invest. That calls for knowledge to be freely shared. The time for talking about open access is now past. With these agreements, we are going to achieve it in practice.”

The League of European Research Universities called the decision “a major boost for the transition towards and Open Science system”.

But while the council has called for immediate open access “without embargoes or with as short as possible embargoes”, some said the 2020 target was unrealistic.

A spokesperson for the council told Science magazine that it “may not be an easy task”, but spoke of the council’s resolve. “This is not a law, but it’s a political orientation for the 28 governments. The important thing is that there is a consensus.”


Age: 36 months Observers 0 Views : 645 Owner: Dagger_69
Owner: Dagger_69
Sealed in 02 April 2020 01:51:43
Opened at: 30 April 2020 00:00:00



Age: 4 weeks Observers 0 Views : 108
Sealed in 03 March 2015 18:21:00
Opened at: 25 April 2020 09:00:00
Sealed with Dogecoin Declassified: WWII German flying "Discs" aircraft

The US 415th NFS encountered German disc weapons launched from BELOW their aircraft over German-held territory which interfered with the aircraft's prop engines. OFFICIAL (key word) photographs and "Foo Fighter" documentation of these German weapons exist and are available to the public despite the USAAF never explaining what that weapon was. Second, other OFFICIAL US Army and AAF Technical Intelligence Reports from 1945 list similar strange flight craft encountered over the Reich in the last year of the war. Jim Wilson of Popular Mechanics magazine researched this material for an article and through FOIA (Freedom of Information Act) documents discovered that the modern USAF ADMITTED by 1995 that the Germans possessed flight discs but only conceded that they were "inherently unstable". No proper identification of those discs nor photos were disclosed. In fact, further classified German discs are not to be declassified until 2020 and the Kahla Complex where they were to be manufactured until 2045. There is also the problem of known German varied disc and circular aircraft programs that can be properly identified which include Focke's Fw Rochen patent, Sack's AS-6V-1, Epps Omega Diskus test models, Schaubergers Repulsin discoid motors, and Schwenteit Elektrische Luft Turbine und Raumschiff patent postwar that is credited as a Schriever/Miethe disc design from WW2 (the mystery V-7). All this evidence is readily available and in print as well. You might consider the German evidence as well from Luftwaffe Sonderburo 13 which was tasked with covering up civilian and military sightings of strange craft over the Reich. On September 29, 1944 a Me-262 pilot on a test run spotted the Andromeda Gerat cylindrical raumschiff traveling at 1,200 mph. His report to Sonderburo 13 is OFFICIAL and on file (although the jet pilot had no idea what the unmarked 348 foot long object was). Sonderburo 13 covered it up as an unknown Allied craft. Finally, there is the postwar evidence of a race to build these type craft as evidenced by AVRO Canada's disc designs (16 of them) and US disc designs now being declassified by Lockheed, Northrop, and NASA.

More information:

Age: 63 months Observers 1 Has 1 observer Views : 802 Owner: Dagger_69
Owner: Dagger_69
Sealed in 19 April 2020 20:46:40
Opened at: 25 April 2020 00:00:00
Guess the number

Number: 52
Prize: EDVD

Age: 5 days Observers 0 Views : 118 Owner: Senoc
Owner: Senoc
Sealed in 23 April 2020 07:50:10
Opened at: 24 April 2020 00:45:00
Sealed with Dogecoin My hopes

At 8:41 BST i am writing this in hope someone sees this and realises the mistakes that have been made and hopefully someone can come and correct these mistakes

Age: 17 hours Observers 0 Views : 102
Sealed in 11 April 2020 09:51:34
Opened at: 21 April 2020 05:00:00
Sealed with Dogecoin CORONAVIRUS cases in Bulgaria will surpass 1500 after the Easter holidays

My prediction is based about the increasing number of people thinking that the pandemic measures are exaggerated and not reasonable at all.

Like the old Bulgarian proverb says: "The Vlach people drown at the end of Danube"

Age: 1 week Observers 0 Views : 124 Owner: DaggerOFF Time
Owner: DaggerOFF Time
Sealed in 20 April 2020 18:44:20
Opened at: 20 April 2020 18:44:20
Time travellers only

Time travellers, feel free to meet with me at this location= (38°53'33"N 76°49'48"W). Feel free to wear whatever clothing that permits you to blend in. You can text me at ( I will not disclose any information you give me. I look forward to having an awesome discussion with you all. ~Tyc

Age: 0 minute Observers 0 Views : 124 Owner: Popo
Owner: Popo
Sealed in 01 March 2020 20:37:38
Opened at: 19 April 2020 00:00:00


Age: 2 months Observers 0 Views : 115
Sealed in 17 April 2020 17:00:22
Opened at: 18 April 2020 18:00:00
Prediction 1

finding out about this time capsule website today

Age: 1 day Observers 0 Views : 109 Owner: Adrian
Owner: Adrian

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